Alveolar Surface Tension Pdf Download

A problem was encountered providing the content you requested Please try again later or contact our Customer Service team providing the below reference numberKeywords:Alveolar macrophageSurfactantZymosanCalciumPKCor its licensors or contributorsCopyright 2016 Elsevier B.VPreviewUnable to display preview.Download preview PDF.Unable to display preview.Download preview PDFReference Number: 18.8c5e6cc1.1504114236.428a4416 Inflammation ResearchOctober 2008, Volume 57, Issue10, pp 489496Inhibition of Ca2+ influx by surfactant in NR8383 alveolar macrophagesAuthorsAuthors and affiliationsR.CastroEmail authorX.H.SunX.-B.LiuJ.R.MartinezG.H.ZhangArticleFirst Online: 02 October 2008 82 Downloads For more information, visit the cookies pageScienceDirect is a registered trademark of Elsevier B.V.

Beractant inhibited the [Ca2+]i by PKC stimulation with DOG and all preparations reduced the MAPK-induced Ca2+influx by C6CElsevier About ScienceDirect Remote accessShopping cart Contact and supportTerms and conditionsPrivacy policy Cookies are used by this siteElsevier About ScienceDirect Remote accessShopping cart Contact and supportTerms and conditionsPrivacy policy Cookies are used by this siteThis anti-inflammatory activity may be through an interaction with downstream signaling elements or Ca2+ channelsor its licensors or contributors

Stimpson 6 May 2008Zymosan-stimulated TNF- and IL-1 secretion was also inhibited by surfactant pretreatment.Conclusions:These results indicate that exogenous surfactant inhibits Ca2+ influx and cytokine secretion in zymosan-stimulated AMsA problem was encountered providing the content you requested Please try again later or contact our Customer Service team providing the below reference numberReference Number: 18.8c5e6cc1.1504114236.428a43d9 We studied the effects of surfactant preparations on Ca2+influx regulated by protein kinase C (PKC) and mitogen-activated protein kinases (MAPK) and cytokine secretion in the alveolar macrophage (AM) cell line NR8383.Methods:Fura-2-loaded AMs were stimulated with zymosan (200g/ml), 1,2-dioctanoyl-sn-glycerol (DOG, 20 M) or C6-ceramide (C6C, 10 M) in the presence of exogenous surfactants (beractant, calfactant or colfosceril) or surfactant phospholipid (dipalmitoyl phosphatidylcholine, DPPC), at 250g/ml phospholipid and changes in cytosolic free Ca 2+ ([Ca2+]i) and cytokines were measured.Results:Zymosan-induced [Ca2+]i (117 5 nM) at 3min was reduced (p <0.001) by beractant (50 6 nM), colfosceril (61 2 nM), calfactant (46 5 nM), and DPPC (52 5 nM)

Abstract.Objective:Pulmonary surfactants reduce alveolar surface tension and alter inflammatory cell functionFor more information, visit the cookies pageCopyright 2016 Elsevier B.VBeractant and Ca2+channel blocker SKF 96365 (10M) together abolished the zymosan-stimulated [Ca2+]iReceived 28 December 2006; returned for revision 10 April 2007; received from final revision 3 March 2008; accepted by SCopyright informationBirkhaueser2008Authors and AffiliationsR.Castro1Email authorX.H.Sun1X.-B.Liu1J.R.Martinez1G.H.Zhang121.Department of PediatricsUniversity of Texas Health Science CenterSan AntonioUSA2.National Center for Research ResourcesNational Institutes of HealthBethesdaUSA

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