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JSci80: F72, 1999)+2 if the treatment worked, or +3 if you relapsed when it was discontinued.We now eliminate about half of chronic infections using a combination of pegylated interferon and ribavirin128: 901, 2004)*"Brown pigment stones" appear in the presence of longstanding infection, especially by ascaris or clonorchis, within the bile ducts rather than the gall bladderThe liver's ability to regenerate is legendaryLIVER ABSCESSES, in the U.SThe infection in kids is usually asymptomaticIt seems to permit the exit of iron from cells -- its inhibition by hepcidin from angry macrophages and IL6-stimulated liver is the basis for anemia of chronic diseaseof Michigan Primary sclerosing cholangitisOnion-skinning around bile duct KU Collection Sclerosing cholangitis Trichrome stain WebPath Sclerosing cholangitis WebPath OTHER INFECTIONS: Malaria can load the Kupffer cells with pigment, but seldom causes hepatic dysfunctionGastro

Tobacco smokers may or may not be barred from receiving a liver; they do worse than non-smokersThese findings are more ominous when the patient has chronic hepatitis clinically: a heavy inflammatory infiltrate of lymphocytes (and often other cells), spilling from the portal areas into the parenchyma; INTERFACE HEPATITIS (formerly "piecemeal necrosis") apoptosis of cells at the edge of the inflammatory infiltrate, causing disruption of the limiting plate of liver cells; BRIDGING NECROSIS, confluent-lytic areas in which all hepatocytes have died (lytic necrosis), leaving behind only collapsed reticulin stroma; FIBROSIS, radiating outward from the portal areas, eventually linking the portal areas to the central areas Cirrhosis Drug-induced liver disease (most notably methotrexate), Wilson's, alpha-1 antitrypsin deficiency, and the autoimmune "lupoid" hepatitis family also typically pass through a "chronic active hepatitis" histopathology stage on their way to cirrhosisEach year approximately 750,000 Americans have their gallbladder removedMore about the emerging regimens, which can work even for the hard-to-treat genetype1 strain: Lancet 385: 1107, 2015ProcMedCurrent thinking supports popular wisdom that alcohol itself does the damage (in fatty change and the more severe forms of "alcoholic liver disease")In primary iron storage disease, it is important to make the diagnosis earlyThere is often extensive fibrosis prior to the onset of symptoms (Arch49: 985, 2003)*Along with rhabdomyosarcoma, hepatoblastoma is more common in children conceived with assisted conception -- most other pediatric cancers aren't (NEJM 369: 1819, 2013)A few mutant viruses that can affect the immunized are now appearing (EpidSurgJHepatitisA vaccine for post-exposure prophylaxis seems to work about as well as immune globulin: NEJM 357: 1685, 2007 314064f7cc

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