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Case report Case series Population study DescriptiveNon-inferiority trials are designed to demonstrate that a treatment is at least not appreciably less effective than a given reference treatmentTreatment studies[edit]Longitudinal study, Ecological study Cohort study Retrospective Prospective Case-control study (Nested case-control study) Case series Case study Case report Epidemiology/ methods occurrence: Incidence (Cumulative incidence) Prevalence Point Period association: absolute (Absolute risk reduction, Attributable risk, Attributable risk percent) relative (Relative risk, Odds ratio, Hazard ratio) other: Clinical endpoint Virulence Infectivity Mortality rate Morbidity Case fatality rate Specificity and sensitivity Likelihood-ratios Pre/post-test probability Trial/test types In vitro In vivo Animal testing Animal testing on non-human primates First-in-man study Multicenter trial Seeding trial Vaccine trial Analysis of clinical trials Riskbenefit ratio Systematic review Replication Meta-analysis Intention-to-treat analysis Interpretation of results Selection bias Survivorship bias Correlation does not imply causation Null result Category Glossary List of topics

 

Seasonal studies[edit]Additionally, seasonal variations and weather patterns can affect a seasonal study.[2][3]hormone replacement therapy) than subjects who don't have the conditionA longitudinal study assesses research subjects over two or more points in time; by contrast, a cross-sectional study assesses research subjects at only one point in time (so case-control, cohort, and randomized studies are not cross-sectional)Clinical study design is the formulation of trials and experiments, as well as observational studies in medical, clinical and other types of research (e.g., epidemiological) involving human beings.[1] The goal of a clinical study is to assess the safety, efficacy, and / or the mechanism of action of an investigational medicinal product or procedure, or new drug or device that is in development, but potentially not yet approved by a health authority (e.g

 

Superiority trials are designed to demonstrate that one treatment is more effective than a given reference treatmentObservational studies[edit]Some of the considerations here are shared under the more general topic of design of experiments but there can be others, in particular related to patient confidentiality and ethicsRandomized controlled trial Blind trial Non-blind trial Adaptive clinical trial Nonrandomized trial (quasi-experiment) Interrupted time series design (measures on a sample or a series of samples from the same population are obtained several times before and after a manipulated event or a naturally occurring event) - considered a type of quasi-experiment 2Retrieved 26 April 2010Retrieved 26 February 2010This type of study design is often employed when comparing a new treatment to an established medical standard of care, in situations where the new treatment is cheaper, safer or more convenient than the reference treatment and would therefore be preferable if not appreciably less effectiveOutline of types of designs for clinical studies[edit]^ Yamin Khan; Sarah Tilly

 

breast cancer) may be more likely to recall the relevant exposures that they had undergone (e.g"Seasonality: The Clinical Trial Manager's Logistical Challenge" (PDF)Important considerations[edit]Conducting studies in seasonal indications (such as allergies, Seasonal Affective Disorder, influenza, and others) can complicate a trial as patients must be enrolled quicklyThis use of the term "retrospective study" is misleading, however, and should be avoided because other research designs besides case-control studies are also retrospective in orientationv t e Statistics Outline Index Descriptive statistics Continuous data Center Mean arithmetic geometric harmonic Median Mode Dispersion Variance Standard deviation Coefficient of variation Percentile Range Interquartile range Shape Central limit theorem Moments Skewness Kurtosis L-moments Count data Index of dispersion Summary tables Grouped data Frequency distribution Contingency table Dependence Pearson product-moment correlation Rank correlation Spearman's rho Kendall's tau Partial correlation Scatter plot Graphics Bar chart Biplot Box plot Control chart Correlogram Fan chart Forest plot Histogram Pie chart QQ plot Run chart Scatter plot Stem-and-leaf display Radar chart Data collection Study design Population Statistic Effect size Statistical power Sample size determination Missing data Survey methodology Sampling stratified cluster Standard error Opinion poll Questionnaire Controlled experiments Design control optimal Controlled trial Randomized Random assignment Replication Blocking Interaction Factorial experiment Uncontrolled studies Observational study Natural experiment Quasi-experiment Statistical inference Statistical theory Population Statistic Probability distribution Sampling distribution Order statistic Empirical distribution Density estimation Statistical model Lp space Parameter location scale shape Parametric family Likelihood(monotone) Locationscale family Exponential family Completeness Sufficiency Statistical functional Bootstrap U V Optimal decision loss function Efficiency Statistical distance divergence Asymptotics Robustness Frequentist inference Point estimation Estimating equations Maximum likelihood Method of moments M-estimator Minimum distance Unbiased estimators Mean-unbiased minimum-variance RaoBlackwellization LehmannScheff theorem Median unbiased Plug-in Interval estimation Confidence interval Pivot Likelihood interval Prediction interval Tolerance interval Resampling Bootstrap Jackknife Testing hypotheses 1- & 2-tails Power Uniformly most powerful test Permutation test Randomization test Multiple comparisons Parametric tests Likelihood-ratio Wald Score Specific tests Z (normal) Student's t-test F Goodness of fit Chi-squared KolmogorovSmirnov AndersonDarling Lilliefors JarqueBera Normality (ShapiroWilk) Likelihood-ratio test Model selection Cross validation AIC BIC Rank statistics Sign Sample median Signed rank (Wilcoxon) HodgesLehmann estimator Rank sum (MannWhitney) Nonparametric anova 1-way (KruskalWallis) 2-way (Friedman) Ordered alternative (JonckheereTerpstra) Bayesian inference Bayesian probability prior posterior Credible interval Bayes factor Bayesian estimator Maximum posterior estimator Correlation Regression analysis Correlation Pearson product-moment Partial correlation Confounding variable Coefficient of determination Regression analysis Errors and residuals Regression model validation Mixed effects models Simultaneous equations models Multivariate adaptive regression splines (MARS) Linear regression Simple linear regression Ordinary least squares General linear model Bayesian regression Non-standard predictors Nonlinear regression Nonparametric Semiparametric Isotonic Robust Heteroscedasticity Homoscedasticity Generalized linear model Exponential families Logistic (Bernoulli)/ Binomial/ Poisson regressions Partition of variance Analysis of variance (ANOVA, anova) Analysis of covariance Multivariate ANOVA Degrees of freedom Categorical/ Multivariate/ Time-series/ Survival analysis Categorical Cohen's kappa Contingency table Graphical model Log-linear model McNemar's test Multivariate Regression Manova Principal components Canonical correlation Discriminant analysis Cluster analysis Classification Structural equation model Factor analysis Multivariate distributions Elliptical distributions Normal Time-series General Decomposition Trend Stationarity Seasonal adjustment Exponential smoothing Cointegration Structural break Granger causality Specific tests DickeyFuller Johansen Q-statistic (LjungBox) DurbinWatson BreuschGodfrey Time domain Autocorrelation (ACF) partial (PACF) Cross-correlation (XCF) ARMA model ARIMA model (BoxJenkins) Autoregressive conditional heteroskedasticity (ARCH) Vector autoregression (VAR) Frequency domain Spectral density estimation Fourier analysis Wavelet Survival Survival function KaplanMeier estimator (product limit) Proportional hazards models Accelerated failure time (AFT) model First hitting time Hazard function NelsonAalen estimator Test Log-rank test Applications Biostatistics Bioinformatics Clinical trials/ studies Epidemiology Medical statistics Engineering statistics Chemometrics Methods engineering Probabilistic design Process/ quality control Reliability System identification Social statistics Actuarial science Census Crime statistics Demography Econometrics National accounts Official statistics Population statistics Psychometrics Spatial statistics Cartography Environmental statistics Geographic information system Geostatistics Kriging Category Portal Commons WikiProject References[edit].

 

1published by: Pharm-Olam International (POI)Food and Drug Administration)Different types of studies are subject to different types of biasIt can also be to investigate a drug, device or procedure that has already been approved but is still in need of further investigation, typically with respect to long-term effects or cost-effectiveness"Flu, Season, Diseases Affect Trials"Cohort study Prospective cohort Retrospective cohort Time series study Case-control study Nested case-control study Cross-sectional study Community survey (a type of cross-sectional study) Ecological study Other terms[edit]Applied Clinical Trials OnlineEquivalence trials are designed to demonstrate that two treatments are equally effective c16eaae032

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