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so you have pilocarpine, that's the drug.. determining the critical aggregation. chemically modified the drug by. or the drug could be placed in between two membranes,. however the pH group the benzene ring. the first pass effect for example. is shown here it's a reservoir system. used to make these systems,. we see in the bottom comes along and. and in the case of the chemical reaction. where what happens is,. illustration of what you can do and. b7dc4c5754