Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017

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23% of UC had poor VDR vs 7.7 % of controls - March 2019
Adv Clin Exp Med. 2019 Mar 28. doi: 10.17219/acem/97376
&nbspDownload the PDF from VitaminDWiki

&nbspDownload the PDF from VitaminDWiki

Adil Coskun, M.D. M.D. Adil Coskun, M.D. Adil Coskun, Irfan Yavasoglu, M.D., Ibrahim Meteoglu, M.D., Mustafa Unubol, M.D., Burak Yasar, M.D., Serkan Borazan, M.D., Imran Kurt Omurlu, M.D., Vahit Yukselen, M.D., M. Hadi Yasa, M.D.

Background
Ulcerative colitis (UC) is a chronic, inflammatory bowel diseases characterized by uncontrolled inflammatory condition of the colon and rectal mucosa marked by recurrent periods of remission and exacerbation. Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. We aimed to evaluate vitamin d receptor level in biopsy specimen of patients with UC in this study.

Methods
VDR levels were retrospectively studied in colon biopsy specimens of UC patients. The Spearman's rho correlation analysis, The Kolmogorov–Smirnov, Mann Whitney U, and chi-square tests were used for statistical analysis. The p values below 0.05 were considered statistically significant.

Results
Study included 112 UC patients (65 male and 47 female) and 30 controls (19 female and 11 male) who had normal results in biopsy examinations carried out due to various reasons. VDR levels of UC patients were statistically lower than control subjects, and was not associated with duration of the disease and place of involvement.

Conclusions
VDR is an important receptor in the pathogenesis of UC, and optimizing vitamin D levels could have a therapeutic role in UC.

Source: https://vitamindwiki.com/tiki-index.php?page=Ulcerative+Colitis+–+half+have+poor+level+of+Vitamin+D+Receptor+vs+only+one+in+ten+normally+–+June+2017