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This impact could clarify cases of constrictive arachnoiditis and sterile meningitis reported after repeated intrathecal TRIAM injection four Nonetheless, we should point out that CSF investigations concerning markers for cell injury, reminiscent of neuron-specific enolase, S-a hundred, neurofilament heavy chain, tau protein offered no convincing proof of neuronal or SC injury after the intrathecal TRIAM therapy 35 The interaction of substances utilized intrathecally with the MHCII molecule and its function for sterile meningitis stays to be further investigated as other substances with non-crystalline structure may result in this side effect 36 As we didn't investigate the consequences of TRIAM in neuron-SC cocultures concerning myelination, we will only postulate that the late effect on myelination proven on day 23 p.i. could be attributed on an improved SC myelination function.
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Gatekeeper: The individual in control of a affected person's remedy, who decides which specialists and different medical assets a affected person can utilize. All these advantages and the presence of novel medicine designed specifically for intravitreal use have produced an enormous enhance in the variety of intravitreal injections administered.
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