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Triplet mixtures containing a proteasome inhibitor are a regular of care in newly identified a number of myeloma (NDMM). Discontinuation of the trial treatment owing to an an infection occurred in zero.5% of the sufferers in the daratumumab group and in 1.4% of the patients within the management group; no patients within the daratumumab group, as compared with 1 patient (zero.three%) within the management group, discontinued treatment due to neutropenia.
what is the cost of lenalidomide after ASCT is related to the next frequency of Grade 3 or four thrombocytopenia compared to placebo upkeep (37.5% vs 30.three% 17.9% vs 4.1% after the beginning of maintenance treatment in CALGB 100104 and thirteen.0% vs 2.9% in IFM 2005-02, respectively).
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Lenalidomide maintenance remedy improved median progression-free survival in patients with del(17p) compared with observation (29 months vs 14 months), whereas these with t(4;14) did not have a benefit (28 months vs 24 months), most likely because of the small pattern measurement.
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