Cytisine - an overview - ScienceDirect Topics

Cytisine = 99 , powder 485-35-8

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Laburnum, which includes cytisine. It showed teratogenic effect in bunnies and poultry. It is a respiratory stimulant, with nicotine-like activity, and a hallucinogenic. However, pharmacologically, cytisine appears to be a prospective restorative utility in aiding smoking cigarettes cessation. In addition, it has shown analgesic, antihypertensive, inotropic, antispasmodic, antioxidant, and insecticidal activities.

The results of hazardous doses consist of weakness, lightheadedness, disability of motor coordination, muscular facial twitches, increased reflex level of sensitivity, mydriasis, shallow breathing, occasional urinary retention, and eventually, tonic-clonic convulsions followed by collapse and coma with respiration cessation, generally caused by paralysis of respiratory muscles. 485-35-8 C11H14N2O C1C2CNCC1C3=CC=CC(=O)N3C2 Harborne JB, Baxter H and Moss GP (1999 ).

Second edition, TJ International Ltd, Padstow, UK. Rouden J, Lasne MC, Blanchet J, and Baudoux J (2014 ). Evaluation: ()-Cytisine and Derivatives: Synthesis, Reactivity, and Applicationserome. Chem. Rev. 114: 712778. cytisine reddit , Zatoski W (2006 ). Review - Cytisine for the treatment of nicotine dependency: from a particle to restorative efficacy. Pharmacological reports 58,777-798.

Placebo-Controlled Trial of Cytisine for Smoking Cessation - NEJM

Synthesis and initial pharmacological examination of some cytisine derivatives. Farmaco, 1999, 54, 438451.

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Cytisine for Smoking Cigarettes Cessation: A Literature Evaluation and a Meta-analysis Etter JFArch Intern Medication. 2006; 166:1553 -1559 To examine the effectiveness of an alkaloid derivative of the plant Cytisus laburnum L., or golden rain tree, called cytisine (not to be puzzled with cytosine or cysteine), an evaluation of the literature and a meta-analysis were carried out.

The studies, all from Bulgaria, Germany, Poland, and Russia, included a total of 4404 cigarette smokers treated with cytisine and 3518 controls. Quit/abstinence rates, based on study (not biochemical) evaluation, ranged from 13. 8% to 70% anywhere from 15 days to 14 months following treatment with cytisine. Meta-analysis of the 3 placebo-controlled trials exposed a chances ratio (OR) of 1.

21-3. 06) for short-term outcome of 4 weeks. A separate meta-analysis of the 2 placebo-controlled trials that had long-lasting follow-up discovered a pooled OR of 1. 83 (95% CI, 1. 12-2. 99) for continued abstinence after 3-6 months. One placebo-controlled study reported abstinence rates 2 years post cytisine treatment with an OR of 1.

29-2. 43). The most typical kind of cytisine is a tablet including 1. 5 mg of the active ingredient. Suggested dose is 6 tablets per day (total of 9 mg of cytisine) for the first 3 days with a steady taper to 2 tablets each day by day 25 at which point the treatment is stopped.