The political fights over abortion demand a great deal of attention. But embryos also demand and warrant a meaningful conversation about everything they represent: values, knowledge, family, religion, health, life, death and more. The boundaries of what we are doing with embryos are shifting quickly. Any attempt to shape the future of how we treat them has to engage with these questions now.
In "Self-Organization of the Human Embryo in the Absence of Maternal Tissues," published in 2016, she and her co-authors detailed how, even with no mom in sight, a human embryo is capable of ambling down its developmental path on autopilot, well past the point when it would have normally implanted in the uterus.
After Dr. Zernicka-Goetz and her team's successful experiment, another group, led by Ali Brivanlou at Rockefeller University, cultured embryos to Day 14. There is still more to be discovered within the bounds of the 14-day rule, as Dr. Zernicka-Goetz acknowledges. But many in the scientific community are already anticipating that crucial breakthroughs — the discoveries that might teach us why some babies are born with developmental defects, why some organs fail to grow properly and what causes miscarriages later in pregnancy — await us on the other side.
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Most scientists working on these models, including Dr. Zernicka-Goetz, say the chances are almost nonexistent that any of them, for now, could go on to become a baby. (Models like these are being developed by teams elsewhere in the United States and in Israel, Britain and China, among other places.) In any case, implanting one in a human uterus would be an ethical breach, prohibited in countries that regulate this type of research, and a scientific scandal of the highest order.
But from a research perspective, the most important question is that of fidelity: How similar are these models to the real thing? If they skip a few of the developmental steps that a natural embryo passes through, as the models currently do, can we trust whatever they do next? As a group of scientists and medical ethicists, writing in Nature Methods, argued, if it's not permissible in many countries to create egg-and-sperm embryos specifically for research purposes, why is it ethically preferable to create stem-cell-derived models that will become increasingly similar to natural embryos? And how can we assess their faithfulness to real embryos after 14 days without continuing to learn about the development of natural embryos anyway?
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After the cloning of Dolly the sheep in 1996, Dr. Kass argued in his essay "The Wisdom of Repugnance" that certain prospects — incest, cannibalism and, he would add, human cloning — inspire a revulsion that needs no rationalization. This repugnance, he writes, is a sign that "we intuit and feel, immediately and without argument, the violation of things we rightfully hold dear."
It is too early to tell how President Trump will govern embryo research in his second term. It took until two years into his first administration for the Department of Health and Human Services to address the issue, but its actions were severe: It cut nearly all of its spending on research involving human fetal tissue. To add an extra layer of review for any projects that involved such tissue, the agency appointed an ethics review board whose members included many outspoken opponents of abortion
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In February the president signed an executive order that calls for policy recommendations to protect access to I.V.F. and lower its costs (“because we want more babies,” Mr. Trump said in an accompanying statement).
The administration has a more limited ability to affect the 14-day rule, which in the United States isn’t a law but a guideline. Embryo research and research on fetal tissue are permitted on a state-by-state basis — New York, for example, has no limit on how long embryos may be grown for research purposes, whereas in California the guideline is 12 days — mirroring in some ways the current state of abortion access. The government has imposed restrictions through its federal funding, but much of the research on early human development relies on private funding from wealthy donors, foundations or venture capitalists.
So far, the issue has not yet garnered much public attention. It is possible this lack of awareness reflects the way that abortion — which has always been a proxy for a thousand other questions about gender, social roles and autonomy — has sucked almost all the air out of the room.
But pushing the frontiers of scientific research demands a broader discussion that transcends niche communities, especially in an area that could transform the nature of reproduction.